Glycitin Induced Autophagy to Clear Amyloid Beta and Protects Neuronal Cell in Alzheimer’s Disease

Accumulation of amyloid beta and its toxicity are the common features in Alzheimer’s disease. Autophagy plays an important role development progression disease by causing selfdegradation accumulated from neurons. Glycitin has been found as major phytochemical constituent soybean, which shows neuroprotective function The present study aims to explore glycitin clearance reducing neuronal cells. human microglial cells 3 neuroblastoma cell SHSY-5Y were used current study. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was access viability neuroprotection. Western blotting determine expression levels different proteins. Autophagosome marker (light chain 3) studied using confocal microscopy. Clearance microscopy enzyme-linked immunosorbent assay. We reported that induces autophagy through phosphatidylinositol 3-kinase/protein kinase B pathway. clears associated SHSY-5 Furthermore, light knockdown inhibits effects conclude can be alternate strategy for curing